Banff



Seventh Banff Conference on
Allograft Pathology

June 14 - 18, 2003
University of Aberdeen
Aberdeen, Scotland



 

Abstracts for the Seventh Banff Conference On Allograft Pathology.

1.  Acute antibody-mediated humoral rejection in ABO-compatible and ABO-incompatible renal transplantations: correlation between the histology, C4d deposits in peritubular capillaries and anti-HLA and anti-ABO antibodies.
*Yukiko Kanetsuna, *Yutaka Yamaguchi,** Masahiro Abe,** Shigeru Horita,
**Kazunari Tanabe, **Shohei Fuchinoue, **Hiroshi Toma
*Department of pathology, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan
**Kidney center, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan

2.  ATUBULAR GLOMERULAR CYSTS IN HUMAN CHRONIC ALLOGRAFT NEPHROPATHY
RJ Barnetsonl
, GBM Lindop1, IW Gibson2
1 Department of Pathology, Western Infirmary, Glasgow, UK
2 Department of Pathology, University of Manitoba, Canada

3.

Biopsy Eosinophilia:  A predictor of Renal Graft Dysfunction
A. Halon1D. Jezior2, M. Boratynska2,  D. Kaminska2,  M. Klinger2,  J. Rabczynski1,  D. Patrzałek3 and  P. Szyber3
1 Department of Pathological Anatomy,  Department of Nephrology and Transplantation Medicine   and   3 Department of Vacsular, General and Transplant Surgery, Wroclaw Medical University, Wroclaw, Poland.

4. BK-VIRUS NEPHROPATHY IN THE RENAL ALLOGRAFT:  URINE CYTOLOGY, HISTOLOGY, URINE PCR, IMMUNOHISTOCHEMISTRY AND ELECTRON MICROSCOPIC FINDINGS.
KK Park1, HC Kim2, JG Lee3, YC Chang2, and YN Kang1.
1 Department of Pathology, Keimyung University School of Medicine, Daegu, Korea
2 Kidney Institute

5. C4D: A DIAGNOSTIC MARKER FOR HUMORAL RENAL ALLOGRAFT REJECTION WITH GLOMERULITIS
Kiril Trpkov1,S. Yilmaz2, W. Truong1, H. Benediktsson1
Department of Pathology and Laboratory Medicine and 2Department of Surgery,
University of Calgary, Calgary, Alberta, Canada

6. C4d Staining of Cardiac Allografts Correlates with Alloantibody
R.N. Smith, N. Brousaides, S. Saidman, and A.B. Collins
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114-2696

7.

CAUSES OF IMMUNOSUPPRESSION WITHDRAWAL AFTER PEDIATRIC LIVER TRANPLANTATION A SINGLE CENTER EXPERIENCE
Sonzogni A , Spada M , Torre G, Lucianetti A, Colledan M, Melzi ML, Riva S, Stroppa P, Gridelli B
Liver Transplantation Center, Ospedali Riuniti, Bergamo, Italy

8. COMPLICATIONS OF AMBULANT RENAL TRANSPLANT BIOPSIES
A. Schwarz 1, W. Gwinner 1, M. Hiss 1, J. Radermacher 1, U. Eisenberger 1, M. Mengel 2, H. Haller 1
Department of Nephrology 1, Department of Pathology 2 Hannover Medical School, D-30625 Hannover, Germany

9.

COMPUTER IMAGE ANALYSIS OF GLOMERULAR PLANNER AREA IN ITERATIVE BIOPSIES OF PEDIATRIC RENAL GRAFT.
L. Murer, M Della Vella, G Montini, B Andreetta, F Fusaro, C Carasi, G Zacchello.
Department of Pediatrics, University of Padova. Italy

10.

Damage to Peritubular Capillaries in Acute Humoral Rejection of Renal Allografts:  an Ultrastructural Study.
P. Liptak,a E. Kemeny,a Z. Morvay,b E. Szederkenyi,c P. Szenohradszky, c F. Marofka,c J. Toldid , H. Regele,e M. Exnere and B. Ivanyia
Departments of aPathology, bRadiology and cSurgery, University of Szeged, Szeged, Hungary; dRegional Transfusion Centre of the NBTS, Szeged, Hungary; Clinical Institute of Pathology and Department of Laboratory Medicine, University of Vienna, Vienna, Austria

11. DE NOVO DIABETIC NEPHROPATHY (DN) ON RENAL ALLOGRAFTS
T. Rott1, A. Hvala1, M. Koselj2, M Koselj-Kajtna3, A Kandus3
1Institute of Pathology, Faculty of Medicine, 2Department of Endocrinology and Diabetes, 3Department of Nephrology, University Medical Centre, Ljubljana, Slovenia

12. DETACHED PODOCYTES IN HUMAN ATUBULAR GLOMERULI  IN CHRONIC ALLOGRAFT NEPHROPATHY
RJ Barnetsonl, IW Gibson2 , GBM Lindop1
1 Department of Pathology, Western Infirmary, Glasgow, UK
2 Department of Pathology, University of Manitoba, Canada

13. DIFFERENTIAL PROTECTIVE EFFECTS OF CALCINEURIN INHIBITORS IN AN IN VITRO MODEL OF HUMAN TUBULAR EPITHELIAL CELLS UNDER OXIDATIVE STRESS.
Dr CE Nolan1, Dr AG Jardine2, Mr JLR Forsythe3 and Dr PG Shiels1.
1 University Department Surgery, Western Infirmary, Glasgow G11 6NT, 2 Dept. Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, 3 Dept Transplant Surgery, Edinburgh Royal Infirmary, Edinburgh EH3 9YW.

14. Donor-Specific Antibody Shows Restricted HLA-Specificity Among Kidney Transplant Recipients And Are Often Detectable Only After Allograft Nephrectomy.
0.Adeyi, M.Dl and R. J. Duquesnoy, Ph.D2
1. Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756-0001, USA
2. Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh 15213

15.

Early RAS activation and Coll III upregulation in allograft protocol renal biopsies.
D. Del Prete, R. Graziotto, F.Anglani, M. Ceol, 1ML. Valente, N. Baldan, F. Marchini, L. Bonfante, P. Rigotti, A. D’Angelo, G. Gambaro.
Department of Medical and Surgical Sciences, 1Institute of Anatomical Pathology, University of Padua, Italy

16.

EFFECTIVE STRATEGY FOR THE MANAGEMENT OF BK NEPHROPATHY
M.V. Govani*, S. Tata*, C.L. Phillips* +, M.L. Milgrom#
Division of Nephrology* and Departments of Pathology+ and Surgery#, Indiana University Medical Center, Indianapolis, Indiana, USA

17. EXPANSION OF THE DONOR KIDNEY POOL: EXPERIENCE WITH ACUTE TUBULAR NECROSIS WITH MYOGLOBIN CASTS AND IRON OVERLOADED DONOR KIDNEYS
Billie Fyfe, Bethany Carlisle, Michael Heifets and Mysore S. Anil Kumar
Department of Pathology, Department of Medicine and Department of Surgery, Division of Transplantation
Drexel University College of Medicine, Philadelphia, PA

18. Flow cytometry based detection of HLA alloantibody mediated classical complement activation
M. Wahrmann1,
M. Exner2, H. Regele3, K. Derfler1, G. Körmözci4, K. Lhotta5 G.J. Zlabinger6, G.A. Böhmig1
Dept. of Internal Medicine III1, Dept. of Lab. Medicine2, Inst. of Pathology3, Dept. of Blood Group Serology4, Inst. of Immunology6, University of Vienna, and Dept. of Internal Medicine5, University of Innsbruck, Austria

19. GENE EXPRESSION PROFILE OF BKV INFECTED WI-38CELLS
Parmjeet S Randhawa, Jian-Hua Luo, Debbie Zygmunt, Uma Chandran, Songhui Li, John Gilbertson
Divisions of Molecular-Cellular Pathology,Transplantation Pathology & Informatics, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.

20. GENE EXPRESSION PROFILING OF BRONCHOALVEOLAR LAVAGE CELLS IN ACUTE LUNG REJECTION
J. Lande, V. Gimino, T. Berryman, R.A. King, and M.I. Hertz
Department of Medicine and Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, United States

21.

HIGH RELIABILITY IN USING BANFF CLASSIFICATION TO MONITOR RENAL ALLOGRAFT REJECTION IN CYNOMOLGUS MACAQUES.
Grazyna Wieczorek1, Sabine Riesen1, Antje Marcantonio1, Klaus Menninger1, Michael J Mihatsch2, Volker Nickeleit3 and Marc Bigaud1 
1Transplantation Research, Novartis Pharma AG, Basel, Switzerland and 2Institute for Pathology, University of Basel, Basel, Switzerland and3Nephropathology Laboratory, University of North Carolina, Chapel Hill, USA.

22.

Histological analysis of renal graft biopsies in antidonor antibody positive patients with capillary C4d deposition more than one year after transplantation.
Kumi Aita1), Yutaka Yamaguchi2), Tomokazu Shimizu3), Shigeru Horita3), Miyuki Furusawa3), Kazunari Tanabe3), Shouhei Fuchinoue3) and Hiroshi Toma3)
1)Department of Pathology, Toranomon Hospital, Tokyo, Japan
2)Department of Pathology, Kashiwa Hospital, Jikei University, Chiba, Japan
3) Kidney Center, Tokyo Women’s Medical University, Tokyo, Japan

23. HISTOLOGIC CHARACTERIZATION OF THE IMMUNE RESPONSE TO RENAL ALLOGRAFTS IN PATIENTS RECEIVING AGGRESSIVE DEPLETIONAL INDUCTION PROTOCOLS
DE Kleinerl, LC Cendales2, DA Hale2, RB Mannon2, SJ Swanson2, AD Kirk2
lLaboratory of Pathology, NCI, Bethesda, MD, 20892 and 2Transplantation and Autoimmunity Branch, NIDDK, Bethesda, MD, 20892

24.

Incidence of C4d staining in protocol biopsies of stable renal allografts: A multicenteR study
M. Mengel1, J. Bogers2, D. Serón3, W. Gwinner4 and H. Haller4 for the ESPRIT5 Group
1Institut fuer Pathologie, Medizinische Hochschule Hannover, Hannover, Germany
2Laboratorium anatomo – pathologie, Universitair Ziekenhuis Antwerpen, Antwerpen, Belgium
3Servicio de Nefrologia, Hospital Universitario de Bellvitge, Barcelona, Spain
4Abteilung Nephrologie, Medizinische Hochschule Hannover, Hannover,Germany
5European Study Group For Protocol Biopsies In Renal Transplantation

25.

INITIAL AND TRANSIENT C4d-POSITIVE ACUTE HUMORAL REJECTION IN A SENSITIZED CARDIAC GRAFT RECIPIENT MAY TRIGER RECURRENT ACUTE CELLULAR REJECTION
J-P. Duong Van Huyen(1), P. Fornes(1), R. Guillemain(2), C. Amrein(2), P. Chevalier(2), C. Latremouille(2), D. Glotz(3), C. Creput(1), D. Nochy(1) and P. Bruneval(1)
PathologyCardiac Transplantation (2), and Nephrology(3), Hôpital Européen Georges Pompidou, Paris, France

26.

INTERSTITIAL FIBROSIS IN CHRONIC RENAL ALLOGRAFT DYSFUNCTION: A CONSEQUENCE OF TRANSDIFFERENTIATION OF TUBULAR EPITHELIUM TO A MYOFIBROBLAST PHENOTYPE?
Helen Robertson and John A Kirby
Applied Immunobiology Group, University of Newcastle, Newcastle upon Tyne NE2 4HH, U.K.

27.

LIVER TRANSPLANTATION FOR SEVERE INTRAHEPATIC NON- CIRRHOTIC PORTAL HYPERTENSION
Susan C. Abraham, M.D., Emma E. Furth, M.D., and Alyssa M. Krasinskas, M.D. Departments of Pathology, Mayo Clinic, Rochester, MN, USA (SCA), University of Pennsylvania, PA, USA (EEF), and University of Pittsburgh, PA, USA (AMK)

28.

Matrix Metalloproteinases & Their Inhibitors: Cadaveric Versus Live Related Allograft Recipients.
A K Ahmed 1*, E Khedr 1, M El Kossi, A M El Nahas 1 and T S Johnson 1.
1 Sheffield Kidney Institute (University of Sheffield), Northern General Hospital, Sheffield, United Kingdom.

29. MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN CHRONIC RENAL ALLOGRAFT NEPHROPATHY (CAN)
A K Ahmed 1*, E Khedr 1, A M El Nahas 1 and T S Johnson 1.
Sheffield Kidney Institute (University of Sheffield), Northern General Hospital, Sheffield, United Kingdom.

30. Measurement of chronic damage in the donor kidney and graft survival
M A S Ferreira1, A J Howie2, D Adu3 and G W Lipkin31Instituto de Urologia e Nefrologia, Rua Voluntários de São Paulo no 3826, Bairro Redentora, São José do Rio Preto - São Paulo, CEP 15015-200, Brazil, 2Department of Pathology, University of Birmingham, Birmingham, United Kingdom, and 3Department of Nephrology, University Hospital Birmingham NHS Trust, Birmingham, United Kingdom

31.

Neogenisis of nestin positive islet precursor cells from rat
M. Subramaniam, E. Brown, P.G. Shiels, D. Deardon
University of Glasgow
Division of Cancer Sciences and Molecular Pathology
Department of Surgery, Western Infirmary Glasgow
Scotland, UK

32. Pathological Study on the Relationship among C4d, Complement Regulatory Factor CD59 and C5b-9 in Acute Rejection Cases
Shinichi Nishi1),
Naofumi Imai2), Yosuke Ito2), Mitsuhiro Ueno2), Sachiko Fukase2), Yoko Takahashi2), Masaaki Arakawa2), Kazuhide Saito3), Kota Takahashi3), Gejyo Fumitake2)
Blood Purification Center, Niigata University Hospital, Niigata city, Japan 1)
Div of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata city, Japan 2)
Div Urology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata city, Japan 3)

33.

Peritubular Capillary Basement Membrane Multilayering: A Marker of Allograft Nephropathy or Not?
Patricia Campbell, Debra Bergstrom, Sita Gourishankar, Sandra Cockfield, Philip Halloran and Kim Solez, Division of Nephrology, Depts of Medicine and Laboratory Medicine, University of Alberta. Edmonton

34.

PIG KIDNEY TRANSPLANTATION IN BABOONS. OUR EXPERIENCE IN 20 CASES.
Mosquera Reboredo Juan M.1; Vázquez Martul E. 1; Mánez R.2; Alonso Hernández, Angel L.3; Gonzalez Martin M.4
Departament of Pathology1, Transplant Coodination Office2, Nefrologia3 and Departament of Urology4 of "Juan Canalejo Hospital". A Corunia. Spain

35.

POST TRANSPLANT PRODUCTION OF DONOR HLA SPECIFIC ANTIBODIES -CORRELATION WITH TRANSPLANT FAILURE AND GRAFT HISTOLOGY
J.E. Worthington1, S. Martin1, and L.J.McWilliam2
1.Transplantation Laboratory, Manchester Royal Infirmary, Manchester, United Kingdom. 2.Department of Histopathology, Manchester Royal Infirmary, Manchester, United Kingdom.

36. PROPOSED CLASSIFICATION OF HUMAN COMPOSITE TISSUE ALLOGRAFT ACUTE REJECTION
LC Cendales, MD1 and DE Kleiner, MD, PhD2.
lTransplant and Autoimmunity Branch, NIDDK, National Institudes of Health, Bethesda, MD, 20892 and 2National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892 United States of America

37.

RENAL ALLOGRAFT REJECTION. LESSONS FROM ULTRASTRUCTURAL OBSERVATIONS
B. Ivanyi

Department of Pathology, University of Szeged, Szeged, Hungary

38.

REPRODUCIBILITY OF THE MORPHOMETRIC QUANTIFICATION OF VASCULAR LESIONS IN RENAL ALLOGRAFT BIOPSIES.
JL Bosmans1, F Moreso², M Mengel³, D Seron², H Haller4, ME De Broe1 for the European Study Group of Renal Allograft Protocol Biopsies.
1 Department of Nephrology-Hypertension, University Hospital Antwerpen, Antwerpen, Belgium.
² Department of Nephrology, Hospital de Bellvitge, Barcelona, Spain.
³ Department of Pathology, Medizinische Hochschule, Hannover, Germany.
Department of Nephrology, Medizinische Hochschule, Hannover, Germany.

39. RETOSPECTIVE ANALYSYS OF GRANZYME B AND PERFORIN EXPRESSION IN BORDERLINE LESIONS OF KIDNEY BIOPSIES.
Balbarrey Z.; Rial M.; Guardia O.; Hilhenbach G.; Casadei D.; Goldberg J.
Dept. of Pathology and Transplantation. Institute of Nephrology.
Buenos Aires, Argentina

40..

SUBCLINICAL INTRAGRAFT EVENTS: ITERATIVE BIOPSIES FROM THE TIME OF RENAL TRANSPLANTATATION (TX) TO ONE YEAR POST-TX.
L Murer, M Della Vella, G Montini, F Fusaro, B Andreetta, C Carasi, G Zacchello.
Department of Pediatrics-University of Padova, Italy.

41.

TELOMERE EROSION AND ALTERED SENESCENCE ASSOCIATED GENE EXPRESSION IN A RAT TRANSPLANT MODEL OF CHRONIC DYSFUNCTION.
CE Nolan1, SA Joosten2, V van Ham2, MC Borias2, C van Kooten2, LC Paul2, AG Jardine3 and PG Shiels1.
1 University of Glasgow, Division of Cancer Sciences and Mol Pathol, and 3 Division of Cardiovascular and Medical Sciences, Western Infirmary Glasgow, 44 Church St, Glasgow G11 6NT. 2 Dept Nephrology, C3P, Leiden University Medical Center, Albinusdreff2, Leiden, 2333ZA, Netherlands.

42. TGF-b EXPRESSION IN RENAL ALLOGRAFT REJECTION AND CYCLOSPORINE TOXICITY
BH Ozdemir, AN Haberal, B Demirhan, M Haberal*
Baskent University, Faculty of medicine, Departments of Pathology and General Surgery*, Ankara-Turkey

43. THE IMPORTANCE OF GLOMERULAR VON WILLEBRAND FACTOR IN HUMAN RENAL ALLOGRAFTS
Ozdemir BH, Demirhan B, Haberal M*
Departments of Pathology and General Surgery*, Baskent University, Faculty of Medicine
Ankara-Turkey

44. THE ROLE OF MICROVASCULAR INJURY ON STEROID AND OKT3 RESPONSE IN RENAL ALLOGRAFT REJECTION
Ozdemir BH, Demirhan B, Haberal M*
Departments of Pathology and General Surgery*,
Baskent University Faculty of Medicine, Ankara, Turkey

45. TRANSCRIPTOMIC APPROACHES FOR PROGNOSIS AND DIAGNOSIS OF RENAL CHRONIC ALLO­­GRAFT REJECTION
A. Scherer1, A. Krause2, J.R. Walker4, A. Korn3 and F. Raulf1,5
1Novartis Institutes for BioMedical Research/Transplantation, and 2CDRA/Biostatistics, and 3Clinical Research and Development/Transplantation BU, Novartis Pharma AG, Basel, Switzerland, 4Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA.

46. VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION IN RENAL ALLOGRAFT REJECTION AND CYCLOSPORINE TOXICITY
BH Ozdemir, AN Haberal, B Demirhan, M Haberal*
Departments of Pathology and General Surgery*, Baskent University, Faculty of medicine, Ankara-Turkey

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