Seventh Banff Conference on Allograft Pathology

Seventh Banff Conference on
Allograft Pathology

June 14 - 18, 2003
University of Aberdeen
Aberdeen, Scotland

Kim Solez, M.D. and Lorraine C. Racusen, M.D., Course Directors
A. J. Demetris, M.D., Coordinator for Liver Pathology Sessions
E. Rene Rodriguez, M.D., Coordinator for Cardiac Sessions

Sponsored by educational grants from: Fujisawa GmbH, Novartis Pharmaceuticals, Pfizer Inc., SangStat Medical Corporation, Wyeth-Ayerst Pharmaceuticals

Power Point Presentations:

Sunday, 15 June 2003

	King's College Conference Centre
7:30 - 8:00	Welcome, Opening Remarks - Kim Solez* and Lorraine Racusen*

	Plenary session
8:00 - 8:40	Keynote Addresses: Evolution of anti-donor immunity post transplantation - implications for CAN. - Robert Lechler* Clinical Indicators for Renal Allograft Loss. - Larry Agadoa*

	King's College Conference Centre
AM	Real-time Gene Analysis/Microarrays in Transplantation - Phil Halloran, Chair*

8:40 - 9:00	Real-time PCR as a clinical tool in transplantation. - Allan Kirk*

9:00 - 9:20	Impact of recipient age on graft gene expression. - Michael Ishitani*

9:20 - 9:40	Cytokine expression in donor livers. - Johann Pratschke*

9:40 - 10:00	Gene expression changes in ischemia, reperfusion and post ischemic inflammation. - Stefan Schneeberger*

10:20 - 10:40	Gene expression profiles of graft response to transplant injury. - David Perkins*

10:40 - 11:00	Microarray profiling and forms of acute allograft rejection. - Minnie Sarwal*

11:00 - 11:20	Immune response gene expression in cardiac transplantation. - Maria Gerbase de Lima*

11:20 - 11:40	Patterns of gene expression as markers for acute and chronic rejection in lung allografts. - Jeffrey Lande*

11:40 - 12:00	The gene expression profiles in chronic allograft dysfunction. - Tung-Yu Tsui*

12:00 - 12:20	Expression profiling of chronic allograft vasculopathy. - E. Rene Rodriguez*

	King's College Conference Centre
PM	Antibody-mediated rejection/C4d - Robert Colvin, Chair*

1:30 - 1:50	Summary: Data to date regarding C4d staining and anti-donor antibody: sensitivity and specificity. - Robert Colvin*

1:50- 2:10	Humoral alloreactivity, C4d staining and the renal allograft. - Helmut Feucht*

2:10 - 2:30	Donor-specific antibody detection and relevance of low levels of Class II-specific antibodies. - Andrea A. Zachary*

2:30 - 2:50	HLA antibody and donor reactivity and risk for rejection and graft loss. - Ronald Kerman*

3:15 - 3:35	HLA antibody and chronic rejection. - Paul Terasaki*

3:35 - 3:55	Anti-HLA antibody importance of memory vs. de novo responses in Renal Transplants. - Peter Nickerson*

3:55 - 4:15	Differing antibody patterns between ABO- and HLA-incompatible grafts. - Millie Samaniego*

4:15 - 4:35	Rejection and anti-angiotensin II antibodies. - Duska Dragun*

4:35 - 4:55	Biological effects of C4d and C3d. - William M. Baldwin*

Monday, 16 June 2003

	King's College Conference Centre
AM	Parallel session: Monocyte/Macrophages - Andrew Rees, Chair

8:30 - 8:50	Role of macrophages in the diagnostic interpretation of endomyocardial biopsies. - Michael Fishbein*

8:50 - 9:10	Is Transglutaminase the switch between inflammation and scarring in Chronic allograft nephropathy? - Tim Johnson*

9:10 - 9:30	Transfected Macrophages in renal inflammation. - David Kluth*

10:00 - 10:20	Monocyte/macrophages and C4d in renal allografts. - Alex Magil*

10:20 - 10:40	Resolution of injury, apoptosis and macrophages. - Jeremy Hughes*

	Far Linklater Room
AM	Parallel session: Liver - Anthony "Jake" Demetris, Chair

8:00 - 8:30	Lymphocyte apoptosis after human liver transplantation - implications for the liver effect. - Andrew Clouston*

8:30 - 9:00	Dendritic Cells: An overview of current understanding of their role in antigen presentation and immune regulation. - Angus W. Thomson*

9:00 - 9:30	Choice of topic related to liver transplant immunopathology. - David Adams*

10:00 - 10:30	Effector mechanisms of liver injury in rejection and recurrent primary biliary cirrhosis. - John M. Vierling*

10:30 - 11:00	Mechanisms of hepatic tolerogenecity. - Alex Bishop*

	Far Linklater Room
PM	Liver - Anthony "Jake" Demetris, Chair*

1:00 - 1:30	When is treatment of acute rejection needed, pathology perspective. - Chris Bellamy*

1:30 -2:00	Immunopathology of weaning immunosuppression after liver transplantation: How robust is the "tolerance"? - A.J. Demetris*

2:00 - 2:30	Autoimmune hepatitis, clinical/immunologic perspective and how might it be different from rejection. - Albert Czaja*

3:00 - 3:30	Considerations in the clinical diagnosis of autoimmune disease in liver allografts. - James Neuberger*

3:30 - 4:00	Histopathologic differential diagnosis of late liver allograft dysfunction. - Stefan G. Hubscher*

Tuesday, 17 June 2003

	King's College Conference Centre
AM	Updates of Schemas for Diagnosis and Treatment of Allograft Rejection - A. Jake Demetris and Kim Solez, Chairs

8:00 - 8:15	The Banff Schema for renal allograft rejection. - Lorraine Racusen*

8:15 - 8:30	The ISHLT schema for heart allograft rejection. - E. Rene Rodriguez*

8:30 - 8:45	The Banff schema for liver allograft rejection. - A. Jake Demetris*

8:45 - 9:00	The classification of pancreas allograft rejection. - Cinthia Drachenburg*

9:00 - 9:20	Looking back - Reflections on Banff 1991 from Banff 2003. - Doug Wilson*

	King's College Conference Centre
AM *Kidney	Parallel session: Tubulitis - Phil Halloran, Chair

9:40 - 10:00	Correlations of tubulitis in the renal allograft. - Phil Halloran*

10:00 - 10:20	Serial biopsy analysis in rejecting and non-rejection rhesus monkeys with renal allografts. - Margreet Jonker*

10:20 - 10:40	Effector cells and tubulitis in the renal allograft. - Gregg Hadley*

10:40 - 11:00	Complement factors and tubulitis. - Steven Sacks*

11:00 - 11:20	T cells modulation of ischemia-reperfusion injury. - Hamid Rabb*

11:20 - 11:40	Why blockade of the costimulatory pathway (B7-1/CD28) is protective in ischemia? - Marc DeBroe*

12:00 - 1:00	Lunch Talk (Elphinstone Hall) Judging Transplant Function - a History - David Hamilton*

	Far Linklater Room
AM **Heart/Lung*	Parallel session: The 1990 ISHLT-Working formulation for the diagnosis of cardiac allograft rejection. - E. Rene Rodriguez, Chair

9:40 - 10:40	The working formulation. Summary of the 2001 consensus. E. Rene Rodriguez, Rex Neal Smith, and Elizabeth Hammond*

	King's College Conference Centre
PM *Kidney	Parallel session: Tolerance/Accommodation/Immunodepletion - Lorraine Racusen, Chair

1:00 - 1:20	Mechanisms and strategies for tolerance induction.. - Robert Lechler"*

1:20 - 1:40	Immune Signalling and Tolerance. - Alan Kirk*

1:40 - 2:00	The tolerance network. - Eleanor Ramos*

2:00 - 2:20	The pathology of accommodation. - Robert Colvin*

2:40 - 3:00	Immunodepletion protocols and kidney allografting. - Roz Mannon*

3:00 - 3:20	Chimerism of endothelial and parenchymal cells. - Paul Grimm*

	Far Linklater Room
PM **Heart/Lung*	Parallel session: The Pathology of Cardiac Allograft Vasculopathy: Mechanisms and Potential for Early Diagnosis and Therapy - E. Rene Rodriguez, Chair

1:00 - 1:15	Vitronectin (α_vβ₁ integrin) in coronary vasculopathy. - Norman B. Ratliff*

1:15 - 1:30	Delayed type hypersensitivity in cardiac transplant vasculopathy. - Jordan S. Pober*

1:30 - 1:45	Perivascular monocyte/macrophage infiltrates in cardiac allograft vasculopathy. - Michael C. Fishbein*

1:45 - 2:00	Microchimerism in the allograft coronary arteries. - Eloisa Arbustini*

2:00 - 2:15	The role of Nitric oxide synthases in cardiac allograft vasculopathy. - Claus B. Andersen*

2:30 - 2:45	The role of complement and immunoglobulins in allograft vasculopathy. - William M. Baldwin*

2:45 - 3:00	Minor antigens are of major importance in chronic graft vasculopathy. - Marlene Rose*

Wednesday, 18 June 2003

	King's College Conference Centre
8:30 - 8:50	Accommodation in ABO-incompatible kidney allografts: graft self-protection via downregulation of genes. - Joseph Grande*

8:50 - 9:10	Summary of UK renal transplant EQA slides. - Ian Roberts*

AM	Plenary Session: Summary statements from previous sessions - Session Chairs Liver Summary Summaries by Session Chairs C4d Positive Definition Monocytes and Macrophages Chair Report - Cardiology

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michele.hales@ualberta.ca