Sixth Banff Conference on Allograft Pathology

Seventh Banff Conference on
Allograft Pathology

June 14 - 18, 2003
University of Aberdeen
Aberdeen, Scotland

Abstracts for the Seventh Banff Conference On Allograft Pathology.

1.	Acute antibody-mediated humoral rejection in ABO-compatible and ABO-incompatible renal transplantations: correlation between the histology, C4d deposits in peritubular capillaries and anti-HLA and anti-ABO antibodies. Yukiko Kanetsuna, Yutaka Yamaguchi, Masahiro Abe, Shigeru Horita, Kazunari Tanabe, Shohei Fuchinoue, *Hiroshi Toma Department of pathology, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan **Kidney center, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan
2.	ATUBULAR GLOMERULAR CYSTS IN HUMAN CHRONIC ALLOGRAFT NEPHROPATHY RJ Barnetson^l, GBM Lindop¹, IW Gibson² 1 Department of Pathology, Western Infirmary, Glasgow, UK 2 Department of Pathology, University of Manitoba, Canada
3.	Biopsy Eosinophilia: A predictor of Renal Graft Dysfunction A. Halon¹, D. Jezior², M. Boratynska², D. Kaminska², M. Klinger², J. Rabczynski¹, D. Patrzałek³and P. Szyber³ ¹Department of Pathological Anatomy, ²Department of Nephrology and Transplantation Medicine and ³Department of Vacsular, General and Transplant Surgery, Wroclaw Medical University, Wroclaw, Poland.
4.	BK-VIRUS NEPHROPATHY IN THE RENAL ALLOGRAFT: URINE CYTOLOGY, HISTOLOGY, URINE PCR, IMMUNOHISTOCHEMISTRY AND ELECTRON MICROSCOPIC FINDINGS. KK Park¹, HC Kim2, JG Lee³, YC Chang², and YN Kang¹. ¹Department of Pathology, Keimyung University School of Medicine, Daegu, Korea ² Kidney Institute
5.	C4D: A DIAGNOSTIC MARKER FOR HUMORAL RENAL ALLOGRAFT REJECTION WITH GLOMERULITIS Kiril Trpkov¹,S. Yilmaz², W. Truong¹, H. Benediktsson¹ Department of Pathology and Laboratory Medicine and ²Department of Surgery, University of Calgary, Calgary, Alberta, Canada
6.	C4d Staining of Cardiac Allografts Correlates with Alloantibody R.N. Smith, N. Brousaides, S. Saidman, and A.B. Collins Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114-2696
7.	CAUSES OF IMMUNOSUPPRESSION WITHDRAWAL AFTER PEDIATRIC LIVER TRANPLANTATION A SINGLE CENTER EXPERIENCE Sonzogni A , Spada M , Torre G, Lucianetti A, Colledan M, Melzi ML, Riva S, Stroppa P, Gridelli B Liver Transplantation Center, Ospedali Riuniti, Bergamo, Italy
8.	COMPLICATIONS OF AMBULANT RENAL TRANSPLANT BIOPSIES A. Schwarz ¹, W. Gwinner ¹, M. Hiss ¹, J. Radermacher ¹, U. Eisenberger ¹, M. Mengel ², H. Haller ¹ Department of Nephrology ¹, Department of Pathology ² Hannover Medical School, D-30625 Hannover, Germany
9.	COMPUTER IMAGE ANALYSIS OF GLOMERULAR PLANNER AREA IN ITERATIVE BIOPSIES OF PEDIATRIC RENAL GRAFT. L. Murer, M Della Vella, G Montini, B Andreetta, F Fusaro, C Carasi, G Zacchello. Department of Pediatrics, University of Padova. Italy
10.	Damage to Peritubular Capillaries in Acute Humoral Rejection of Renal Allografts: an Ultrastructural Study. P. Liptak,^a E. Kemeny,^a Z. Morvay,^b E. Szederkenyi,^c P. Szenohradszky,^c F. Marofka,^c J. Toldi^d , H. Regele,^e M. Exner^eand B. Ivanyi^a Departments of ^aPathology, ^bRadiology and ^cSurgery, University of Szeged, Szeged, Hungary; ^dRegional Transfusion Centre of the NBTS, Szeged, Hungary; Clinical Institute of Pathology and Department of Laboratory Medicine, University of Vienna, Vienna, Austria
11.	DE NOVO DIABETIC NEPHROPATHY (DN) ON RENAL ALLOGRAFTS T. Rott¹, A. Hvala¹, M. Koselj², M Koselj-Kajtna³, A Kandus³ ¹Institute of Pathology, Faculty of Medicine, ²Department of Endocrinology and Diabetes, ³Department of Nephrology, University Medical Centre, Ljubljana, Slovenia
12.	DETACHED PODOCYTES IN HUMAN ATUBULAR GLOMERULI IN CHRONIC ALLOGRAFT NEPHROPATHY RJ Barnetson^l, IW Gibson², GBM Lindop¹ 1 Department of Pathology, Western Infirmary, Glasgow, UK 2 Department of Pathology, University of Manitoba, Canada
13.	DIFFERENTIAL PROTECTIVE EFFECTS OF CALCINEURIN INHIBITORS IN AN IN VITRO MODEL OF HUMAN TUBULAR EPITHELIAL CELLS UNDER OXIDATIVE STRESS. Dr CE Nolan¹, Dr AG Jardine², Mr JLR Forsythe³ and Dr PG Shiels¹. ¹ University Department Surgery, Western Infirmary, Glasgow G11 6NT,² Dept. Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, ³ Dept Transplant Surgery, Edinburgh Royal Infirmary, Edinburgh EH3 9YW.
14.	Donor-Specific Antibody Shows Restricted HLA-Specificity Among Kidney Transplant Recipients And Are Often Detectable Only After Allograft Nephrectomy. 0.Adeyi, M.D^l and R. J. Duquesnoy, Ph.D² 1. Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756-0001, USA 2. Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh 15213
15.	Early RAS activation and Coll III upregulation in allograft protocol renal biopsies. D. Del Prete, R. Graziotto, F.Anglani, M. Ceol, ¹ML. Valente, N. Baldan, F. Marchini, L. Bonfante, P. Rigotti, A. D’Angelo, G. Gambaro. Department of Medical and Surgical Sciences, ¹Institute of Anatomical Pathology, University of Padua, Italy
16.	EFFECTIVE STRATEGY FOR THE MANAGEMENT OF BK NEPHROPATHY M.V. Govani, S. Tata^, C.L. Phillips* ⁺, M.L. Milgrom^# Division of Nephrology* and Departments of Pathology⁺ and Surgery^#, Indiana University Medical Center, Indianapolis, Indiana, USA
17.	EXPANSION OF THE DONOR KIDNEY POOL: EXPERIENCE WITH ACUTE TUBULAR NECROSIS WITH MYOGLOBIN CASTS AND IRON OVERLOADED DONOR KIDNEYS Billie Fyfe, Bethany Carlisle, Michael Heifets and Mysore S. Anil Kumar Department of Pathology, Department of Medicine and Department of Surgery, Division of Transplantation Drexel University College of Medicine, Philadelphia, PA
18.	Flow cytometry based detection of HLA alloantibody mediated classical complement activation M. Wahrmann¹, M. Exner², H. Regele³, K. Derfler¹, G. Körmözci⁴, K. Lhotta⁵ G.J. Zlabinger⁶, G.A. Böhmig¹ Dept. of Internal Medicine III¹, Dept. of Lab. Medicine², Inst. of Pathology³, Dept. of Blood Group Serology⁴, Inst. of Immunology⁶, University of Vienna, and Dept. of Internal Medicine⁵, University of Innsbruck, Austria
19.	GENE EXPRESSION PROFILE OF BKV INFECTED WI-38CELLS Parmjeet S Randhawa, Jian-Hua Luo, Debbie Zygmunt, Uma Chandran, Songhui Li, John Gilbertson Divisions of Molecular-Cellular Pathology,Transplantation Pathology & Informatics, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
20.	GENE EXPRESSION PROFILING OF BRONCHOALVEOLAR LAVAGE CELLS IN ACUTE LUNG REJECTION J. Lande, V. Gimino, T. Berryman, R.A. King, and M.I. Hertz Department of Medicine and Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, United States
21.	HIGH RELIABILITY IN USING BANFF CLASSIFICATION TO MONITOR RENAL ALLOGRAFT REJECTION IN CYNOMOLGUS MACAQUES. Grazyna Wieczorek¹, Sabine Riesen¹, Antje Marcantonio¹, Klaus Menninger¹, Michael J Mihatsch², Volker Nickeleit³ and Marc Bigaud¹ ¹Transplantation Research, Novartis Pharma AG, Basel, Switzerland and ²Institute for Pathology, University of Basel, Basel, Switzerland and³Nephropathology Laboratory, University of North Carolina, Chapel Hill, USA.
22.	Histological analysis of renal graft biopsies in antidonor antibody positive patients with capillary C4d deposition more than one year after transplantation. Kumi Aita¹⁾, Yutaka Yamaguchi²⁾, Tomokazu Shimizu³⁾, Shigeru Horita³⁾, Miyuki Furusawa³⁾, Kazunari Tanabe³⁾, Shouhei Fuchinoue³⁾ and Hiroshi Toma³⁾ 1)Department of Pathology, Toranomon Hospital, Tokyo, Japan 2)Department of Pathology, Kashiwa Hospital, Jikei University, Chiba, Japan 3) Kidney Center, Tokyo Women’s Medical University, Tokyo, Japan
23.	HISTOLOGIC CHARACTERIZATION OF THE IMMUNE RESPONSE TO RENAL ALLOGRAFTS IN PATIENTS RECEIVING AGGRESSIVE DEPLETIONAL INDUCTION PROTOCOLS DE Kleiner^l, LC Cendales², DA Hale², RB Mannon², SJ Swanson², AD Kirk² ^lLaboratory of Pathology, NCI, Bethesda, MD, 20892 and ²Transplantation and Autoimmunity Branch, NIDDK, Bethesda, MD, 20892
24.	Incidence of C4d staining in protocol biopsies of stable renal allografts: A multicenteR study M. Mengel¹, J. Bogers², D. Serón³, W. Gwinner⁴ and H. Haller⁴ for the ESPRIT⁵ Group ¹Institut fuer Pathologie, Medizinische Hochschule Hannover, Hannover, Germany ²Laboratorium anatomo – pathologie, Universitair Ziekenhuis Antwerpen, Antwerpen, Belgium ³Servicio de Nefrologia, Hospital Universitario de Bellvitge, Barcelona, Spain ⁴Abteilung Nephrologie, Medizinische Hochschule Hannover, Hannover,Germany ⁵European Study Group For Protocol Biopsies In Renal Transplantation
25.	INITIAL AND TRANSIENT C4d-POSITIVE ACUTE HUMORAL REJECTION IN A SENSITIZED CARDIAC GRAFT RECIPIENT MAY TRIGER RECURRENT ACUTE CELLULAR REJECTION J-P. Duong Van Huyen⁽¹⁾, P. Fornes⁽¹⁾, R. Guillemain⁽²⁾, C. Amrein⁽²⁾, P. Chevalier⁽²⁾, C. Latremouille⁽²⁾, D. Glotz⁽³⁾, C. Creput⁽¹⁾, D. Nochy⁽¹⁾ and P. Bruneval⁽¹⁾ PathologyCardiac Transplantation⁽²⁾, and Nephrology⁽³⁾, Hôpital Européen Georges Pompidou, Paris, France
26.	INTERSTITIAL FIBROSIS IN CHRONIC RENAL ALLOGRAFT DYSFUNCTION: A CONSEQUENCE OF TRANSDIFFERENTIATION OF TUBULAR EPITHELIUM TO A MYOFIBROBLAST PHENOTYPE? Helen Robertson and John A Kirby Applied Immunobiology Group, University of Newcastle, Newcastle upon Tyne NE2 4HH, U.K.
27.	LIVER TRANSPLANTATION FOR SEVERE INTRAHEPATIC NON- CIRRHOTIC PORTAL HYPERTENSION Susan C. Abraham, M.D., Emma E. Furth, M.D., and Alyssa M. Krasinskas, M.D. Departments of Pathology, Mayo Clinic, Rochester, MN, USA (SCA), University of Pennsylvania, PA, USA (EEF), and University of Pittsburgh, PA, USA (AMK)
28.	Matrix Metalloproteinases & Their Inhibitors: Cadaveric Versus Live Related Allograft Recipients. *A K Ahmed ¹,** E Khedr ¹, M El Kossi, A M El Nahas ¹ and T S Johnson ¹. ¹ Sheffield Kidney Institute (University of Sheffield), Northern General Hospital, Sheffield, United Kingdom.
29.	MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN CHRONIC RENAL ALLOGRAFT NEPHROPATHY (CAN) A K Ahmed ¹*, E Khedr ¹, A M El Nahas ¹ and T S Johnson ¹. Sheffield Kidney Institute (University of Sheffield), Northern General Hospital, Sheffield, United Kingdom.
30.	Measurement of chronic damage in the donor kidney and graft survival M A S Ferreira¹, A J Howie², D Adu³ and G W Lipkin³¹Instituto de Urologia e Nefrologia, Rua Voluntários de São Paulo no 3826, Bairro Redentora, São José do Rio Preto - São Paulo, CEP 15015-200, Brazil, ²Department of Pathology, University of Birmingham, Birmingham, United Kingdom, and ³Department of Nephrology, University Hospital Birmingham NHS Trust, Birmingham, United Kingdom
31.	Neogenisis of nestin positive islet precursor cells from rat M. Subramaniam, E. Brown, P.G. Shiels, D. Deardon University of Glasgow Division of Cancer Sciences and Molecular Pathology Department of Surgery, Western Infirmary Glasgow Scotland, UK
32.	Pathological Study on the Relationship among C4d, Complement Regulatory Factor CD59 and C5b-9 in Acute Rejection Cases Shinichi Nishi¹⁾, Naofumi Imai²⁾, Yosuke Ito²⁾, Mitsuhiro Ueno²⁾, Sachiko Fukase²⁾, Yoko Takahashi²⁾, Masaaki Arakawa²⁾, Kazuhide Saito³⁾, Kota Takahashi³⁾, Gejyo Fumitake²⁾ Blood Purification Center, Niigata University Hospital, Niigata city, Japan ¹⁾ Div of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata city, Japan ²⁾ Div Urology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata city, Japan ³⁾
33.	Peritubular Capillary Basement Membrane Multilayering: A Marker of Allograft Nephropathy or Not? Patricia Campbell, Debra Bergstrom, Sita Gourishankar, Sandra Cockfield, Philip Halloran and Kim Solez, Division of Nephrology, Depts of Medicine and Laboratory Medicine, University of Alberta. Edmonton
34.	PIG KIDNEY TRANSPLANTATION IN BABOONS. OUR EXPERIENCE IN 20 CASES. Mosquera Reboredo Juan M.¹; Vázquez Martul E.¹; Mánez R.²; Alonso Hernández, Angel L.³; Gonzalez Martin M.⁴ Departament of Pathology¹, Transplant Coodination Office², Nefrologia³ and Departament of Urology⁴ of "Juan Canalejo Hospital". A Corunia. Spain
35.	POST TRANSPLANT PRODUCTION OF DONOR HLA SPECIFIC ANTIBODIES -CORRELATION WITH TRANSPLANT FAILURE AND GRAFT HISTOLOGY J.E. Worthington¹, S. Martin¹, and L.J.McWilliam² ^1.Transplantation Laboratory, Manchester Royal Infirmary, Manchester, United Kingdom. ².Department of Histopathology, Manchester Royal Infirmary, Manchester, United Kingdom.
36.	PROPOSED CLASSIFICATION OF HUMAN COMPOSITE TISSUE ALLOGRAFT ACUTE REJECTION LC Cendales, MD¹ and DE Kleiner, MD, PhD². ^lTransplant and Autoimmunity Branch, NIDDK, National Institudes of Health, Bethesda, MD, 20892 and ²National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892 United States of America
37.	RENAL ALLOGRAFT REJECTION. LESSONS FROM ULTRASTRUCTURAL OBSERVATIONS B. Ivanyi Department of Pathology, University of Szeged, Szeged, Hungary
38.	REPRODUCIBILITY OF THE MORPHOMETRIC QUANTIFICATION OF VASCULAR LESIONS IN RENAL ALLOGRAFT BIOPSIES. JL Bosmans¹, F Moreso², M Mengel³, D Seron², H Haller⁴, ME De Broe¹ for the European Study Group of Renal Allograft Protocol Biopsies. ¹Department of Nephrology-Hypertension, University Hospital Antwerpen, Antwerpen, Belgium. ² Department of Nephrology, Hospital de Bellvitge, Barcelona, Spain. ³ Department of Pathology, Medizinische Hochschule, Hannover, Germany. ⁴Department of Nephrology, Medizinische Hochschule, Hannover, Germany.
39.	RETOSPECTIVE ANALYSYS OF GRANZYME B AND PERFORIN EXPRESSION IN BORDERLINE LESIONS OF KIDNEY BIOPSIES. Balbarrey Z.; Rial M.; Guardia O.; Hilhenbach G.; Casadei D.; Goldberg J. Dept. of Pathology and Transplantation. Institute of Nephrology. Buenos Aires, Argentina
40..	SUBCLINICAL INTRAGRAFT EVENTS: ITERATIVE BIOPSIES FROM THE TIME OF RENAL TRANSPLANTATATION (TX) TO ONE YEAR POST-TX. L Murer, M Della Vella, G Montini, F Fusaro, B Andreetta, C Carasi, G Zacchello. Department of Pediatrics-University of Padova, Italy.
41.	TELOMERE EROSION AND ALTERED SENESCENCE ASSOCIATED GENE EXPRESSION IN A RAT TRANSPLANT MODEL OF CHRONIC DYSFUNCTION. CE Nolan¹, SA Joosten², V van Ham², MC Borias², C van Kooten², LC Paul², AG Jardine³ and PG Shiels¹. ¹ University of Glasgow, Division of Cancer Sciences and Mol Pathol, and ³ Division of Cardiovascular and Medical Sciences, Western Infirmary Glasgow, 44 Church St, Glasgow G11 6NT. ² Dept Nephrology, C3P, Leiden University Medical Center, Albinusdreff2, Leiden, 2333ZA, Netherlands.
42.	TGF-b EXPRESSION IN RENAL ALLOGRAFT REJECTION AND CYCLOSPORINE TOXICITY BH Ozdemir, AN Haberal, B Demirhan, M Haberal* Baskent University, Faculty of medicine, Departments of Pathology and General Surgery*, Ankara-Turkey
43.	THE IMPORTANCE OF GLOMERULAR VON WILLEBRAND FACTOR IN HUMAN RENAL ALLOGRAFTS Ozdemir BH, Demirhan B, Haberal M* Departments of Pathology and General Surgery*, Baskent University, Faculty of Medicine Ankara-Turkey
44.	THE ROLE OF MICROVASCULAR INJURY ON STEROID AND OKT3 RESPONSE IN RENAL ALLOGRAFT REJECTION Ozdemir BH, Demirhan B, Haberal M* Departments of Pathology and General Surgery*, Baskent University Faculty of Medicine, Ankara, Turkey
45.	TRANSCRIPTOMIC APPROACHES FOR PROGNOSIS AND DIAGNOSIS OF RENAL CHRONIC ALLOGRAFT REJECTION A. Scherer¹, A. Krause², J.R. Walker⁴, A. Korn³ and F. Raulf^1,5 ¹Novartis Institutes for BioMedical Research/Transplantation, and ²CDRA/Biostatistics, and ³Clinical Research and Development/Transplantation BU, Novartis Pharma AG, Basel, Switzerland, ⁴Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA.
46.	VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION IN RENAL ALLOGRAFT REJECTION AND CYCLOSPORINE TOXICITY BH Ozdemir, AN Haberal, B Demirhan, M Haberal* Departments of Pathology and General Surgery*, Baskent University, Faculty of medicine, Ankara-Turkey

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